KEYNOTE-189: Updated Overall Survival and Progression After the Next Line of Therapy With Pembrolizumab plus Chemotherapy With Pemetrexed and Platinum vs Placebo plus Chemotherapy for Metastatic Nonsquamous Non–Small-Cell Lung Cancer. Study Design, Participants and Treatment
A trial looking at pembrolizumab and chemotherapy for advanced non small cell lung cancer (KEYNOTE-789) Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
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KEYNOTE-789 EGFR + EGFR + Pembrolizumab + chemotherapy Placebo + chemotherapy Ongoing CheckMate 722 EGFR + EGFR + Nivolumab + chemotherapy Placebo + chemotherapy Ongoing NCT03513666 EGFR +, EGFR-TKI pretreated (n = 40) Toripalimab + chemotherapy ORR: 54.8%; DCR: 93.5%; mPFS: 7.6mo 2 + L ICI + ICI KEYNOTE-021 cohorts D and H EGFR +, TKI The role of anti-PD-1 or anti-PD-L1 therapy after first-line tyrosine kinase inhibitor treatment in patients with EGFR mutations is still an open question and is being evaluated in the KEYNOTE-789 study (ClinicalTrials.gov, NCT03515837). Typically, responses occurred early during pembrolizumab therapy and were maintained over extended periods. The KEYNOTE-789, CheckMate 722, and WJOG8515L trials are ongoing enrolling advanced non-squamous NSCLC and EGFR-mutant patients who progressed on prior TKIs therapies, and patients were assigned to Etude : KEYNOTE 789 / MK-3475-789-00 ATTENTION : pour chaque essai clinique, les éléments affichés ci-dessous ne sont pas exhaustifs, et le protocole fourni par le promoteur reste l’unique document à consulter pour mener à bien un essai clinique sur centre. KEYNOTE-189 trial is provided in the Supplementary Appendix, available at NEJM.org. This article was published on April 16, 2018, at NEJM.org. N Engl J Med 2018;378:2078-92.
A Phase 3, Randomized, Double-blind Study of Pembrolizumab (MK-3475) Plus Docetaxel Plus Prednisone Versus Placebo Plus Docetaxel Plus Prednisone in Participants With Chemotherapy-naïve Metastatic Castration-Resistant Prostate Cancer (mCRPC) Who Have Progressed on a Next Generation Hormonal Agent (NHA) (KEYNOTE-921) Actual Study Start Date :
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Targeted therapies are efficient in the context of oncogenic driver mutations. Epidermal growth factor receptor (EGFR)-mutant lung cancers represent a distinct subset of non-small-cell lung cancer
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Study of Pemetrexed + Platinum Chemotherapy With or Without Pembrolizumab (MK-3475) in Adults With Tyrosine Kinase Inhibitor- (TKI)-Resistant Epidermal Growth Factor
Keynote lecturer, preliminary title “Development of consumer behaviour research over time” 203–221, http://www.univie.ac.at/virusss/projects/7/789. Nolin, Jan av F Larsson · 2018 — 789-819.
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The KEYNOTE-789, CheckMate 722, and WJOG8515L trials enrolled patients with advanced non-squamous NSCLC with EGFR mutations who progressed after prior TKI therapies, and patients were assigned to
For this collection, we handpicked some of the best free Keynote templates just for you. Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. 2021-03-23 · New in Keynote 10.0 for Mac. Select from a variety of gorgeous new themes to help you get started. Add a Keynote presentation to a shared iCloud Drive folder to automatically start collaborating.